Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 12/20 | 0.39 |
| ▸ | CCND1 | P24385 | 11/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.39 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16074660 | 1.00 | MAPK8 (0.45) | MAPK8MAPK10MAPK9MAPK14GSK3A | |
| SCHEMBL18637774 | 0.91 | CCND1 (0.44) | MAPK8CDK2CCND1CCNE1CDK6 | |
| SCHEMBL25950600 | 0.80 | MAPK8 (0.46) | MAPK8MAPK10MAPK9MAPK14CDK2 | |
| SCHEMBL18637985 | 0.80 | MAPK8 (0.52) | MAPK8MAPK10MAPK9MAPK14GSK3A | |
| SCHEMBL15298054 | 0.80 | MAPK8 (0.52) | MAPK8MAPK10MAPK9MAPK14GSK3A | |
| SCHEMBL15298252 | 0.79 | CDK2 (0.56) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL18638036 | 0.79 | CDK2 (0.56) | CDK2CCND1CCNE1CDK6CDK4 | |
| SCHEMBL17540002 | 0.76 | MAPK8 (0.52) | MAPK8MAPK10MAPK9MAPK14GSK3A | |
| SCHEMBL15298076 | 0.75 | MAPK8 (0.47) | MAPK8MAPK10MAPK9MAPK14GSK3A | |
| SCHEMBL18638034 | 0.75 | MAPK8 (0.47) | MAPK8MAPK10MAPK9MAPK14GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216792-B1 | LACTAM KINASE INHIBITORS | G1 THERAPEUTICS INC (US) | 2020-05-27 | — | — | EP | disclosed |
| EP-3216792-A1 | LACTAM KINASE INHIBITORS | Tavares, Francis Xavier (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2831080-B1 | LACTAM KINASE INHIBITORS | TAVARES FRANCIS XAVIER (US) | 2017-03-15 | — | — | EP | disclosed |