Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 8/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18639996 | 0.86 | MEN1 (0.44) | MEN1KMT2AL3MBTL1ESR1ROCK2 | |
| SCHEMBL18639994 | 0.84 | HRH3 (0.40) | MEN1KMT2AL3MBTL1ESR1 | |
| SCHEMBL18640072 | 0.82 | HRH3 (0.41) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL18639963 | 0.81 | ESR1 (0.36) | MEN1KMT2AL3MBTL1ESR1GRIN2B | |
| SCHEMBL18640010 | 0.81 | SLC6A2 (0.43) | MAOB | |
| SCHEMBL18639984 | 0.78 | TLR9 (0.39) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL18640039 | 0.77 | EHMT2 (0.37) | MEN1KMT2AL3MBTL1MAPK1ROCK2 | |
| SCHEMBL18640285 | 0.76 | F10 (0.47) | MEN1KMT2AL3MBTL1ROCK2ROCK1 | |
| SCHEMBL18639865 | 0.76 | TLR9 (0.40) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL18664346 | 0.73 | EHMT2 (0.37) | MEN1KMT2AL3MBTL1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |