Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640220 | 0.81 | F10 (0.47) | F10KDM4ESMN1; SMN2KCNH2SCN5A | |
| SCHEMBL18639947 | 0.78 | F10 (0.54) | F10ROCK1KDM4ESMN1; SMN2BCHE | |
| SCHEMBL18640072 | 0.77 | HRH3 (0.41) | KCNH2L3MBTL1MEN1KMT2A | |
| SCHEMBL18639994 | 0.77 | HRH3 (0.40) | L3MBTL1MEN1KMT2A | |
| SCHEMBL18639855 | 0.76 | MEN1 (0.42) | ROCK2ROCK1L3MBTL1MEN1KMT2A | |
| SCHEMBL18640010 | 0.76 | SLC6A2 (0.43) | KCNH2 | |
| SCHEMBL18639996 | 0.74 | MEN1 (0.44) | ROCK2ROCK1L3MBTL1MEN1KMT2A | |
| SCHEMBL18639963 | 0.74 | ESR1 (0.36) | L3MBTL1MEN1KMT2A | |
| SCHEMBL18664105 | 0.74 | F10 (0.49) | F10KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL18664167 | 0.73 | F10 (0.51) | F10KDM4ESMN1; SMN2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |