Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013577 | 0.82 | OPRK1 (0.52) | OPRK1SCN9AHTTOPRD1 | |
| SCHEMBL8925926 | 0.81 | TACR1 (0.50) | TACR1 | |
| SCHEMBL8925928 | 0.81 | TACR1 (0.50) | TACR1 | |
| SCHEMBL3652328 | 0.81 | TACR1 (0.50) | TACR1 | |
| SCHEMBL3015928 | 0.78 | SLC6A2 (0.49) | OPRK1CYP2D6MAPT | |
| SCHEMBL18640306 | 0.77 | CHRNA7 (0.50) | TACR1 | |
| SCHEMBL18640258 | 0.74 | TACR1 (0.47) | TACR1 | |
| SCHEMBL18640230 | 0.73 | TACR1 (0.48) | OPRK1TACR1 | |
| SCHEMBL18640284 | 0.72 | TACR1 (0.47) | OPRK1TACR1 | |
| SCHEMBL18640236 | 0.71 | TACR1 (0.49) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3349743-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | St. Jude Children's Research Hospital (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017049295-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-03-23 | — | — | WO | disclosed |