Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640412 | 0.89 | SYK (0.44) | ROCK2SYKROCK1CAMK2DJAK2 | |
| SCHEMBL18627939 | 0.84 | SYK (0.47) | ROCK2SYKROCK1CAMK2DJAK2 | |
| SCHEMBL18640375 | 0.82 | SYK (0.41) | ROCK2SYKROCK1CAMK2DJAK2 | |
| SCHEMBL18627956 | 0.81 | SYK (0.49) | SYKCAMK2DBRD4CDK1CDK2 | |
| SCHEMBL18627914 | 0.81 | SYK (0.49) | SYKCAMK2DBRD4CDK1CDK2 | |
| SCHEMBL18627901 | 0.81 | SYK (0.49) | SYKCAMK2DBRD4CDK1CDK2 | |
| SCHEMBL18627908 | 0.79 | SYK (0.47) | SYKBRD4CDK1CDK2SMG1 | |
| SCHEMBL18627910 | 0.79 | SYK (0.47) | SYKBRD4CDK1CDK2SMG1 | |
| SCHEMBL18627951 | 0.79 | SYK (0.47) | SYKBRD4CDK1CDK2SMG1 | |
| SCHEMBL18627954 | 0.79 | SYK (0.45) | SYKJAK2CDK1CDK2SMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350176-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB Science (FR) | 2018-07-25 | — | — | EP | claimed |
| WO-2017046302-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2017-03-23 | — | — | WO | claimed |