Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | WEE1 | P30291 | 4/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640412 | 0.89 | SYK (0.44) | SYKROCK1ROCK2WEE1CAMK2D | |
| SCHEMBL18627957 | 0.86 | SYK (0.45) | SYKCAMK2DJAK2BRD4CDK1 | |
| SCHEMBL18627919 | 0.82 | SYK (0.43) | SYKCAMK2DJAK2BRD4CDK1 | |
| SCHEMBL18640240 | 0.82 | ROCK2 (0.42) | SYKROCK1ROCK2CAMK2DJAK2 | |
| SCHEMBL18627938 | 0.78 | SYK (0.57) | SYKCAMK2DJAK2BRD4CDK1 | |
| SCHEMBL17113590 | 0.77 | SYK (0.69) | SYKCAMK2DJAK2BRD4CDK1 | |
| SCHEMBL18627901 | 0.75 | SYK (0.49) | SYKCAMK2DBRD4CDK1CDK2 | |
| SCHEMBL18627914 | 0.75 | SYK (0.49) | SYKCAMK2DBRD4CDK1CDK2 | |
| SCHEMBL18627956 | 0.75 | SYK (0.49) | SYKCAMK2DBRD4CDK1CDK2 | |
| SCHEMBL18627939 | 0.74 | SYK (0.47) | SYKROCK1ROCK2CAMK2DJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350176-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB Science (FR) | 2018-07-25 | — | — | EP | claimed |
| WO-2017046302-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2017-03-23 | — | — | WO | claimed |