Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14094808 | 0.82 | KDM4E (0.43) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL15243578 | 0.78 | TRPV3 (0.31) | — | |
| SCHEMBL21932530 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL18640651 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL29705395 | 0.78 | TRPV3 (0.31) | — | |
| SCHEMBL30128584 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL24618308 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| Hydrochloric Acid SCHEMBL18764595 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL29791961 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL8029116 | 0.76 | KDM4E (0.42) | KDM4EALDH1A1HPGDUSP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046739-A1 | IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-23 | — | — | WO | disclosed |
| WO-2017046739-A1 | IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-23 | — | — | WO | disclosed |