Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102255 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL18646336 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL17102253 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL16428060 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL14659323 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL19947558 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL524313 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL19965134 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL16428059 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL14659325 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119765-B1 | HETEROARYL SYK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-07-17 | — | — | EP | disclosed |
| EP-3119766-B1 | HETEROARYL SYK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |
| EP-3119772-B1 | HETEROARYL SIK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2017042100-A1 | PYRAZOLYL-SUBSTITUTED HETEROARYLS AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-03-16 | — | — | WO | disclosed |