Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102255 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL18646336 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL18645260 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL17102253 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL16428060 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL14659323 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL19947558 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL524313 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL16428059 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB | |
| SCHEMBL14659325 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AHSD11B1HSD17B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072744-A1 | HETEROARYL SYK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072744-A1 | HETEROARYL SYK INHIBITORS | SYK, BTK, CD40 | SMN1; SMN2 4707/4885KMT2A 733/4885HSD11B1 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.