Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | IL1RN | P18510 | 2/20 | 0.30 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.30 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18646270 | 0.85 | DRD2 (0.42) | DRD2DRD3EPAS1FFAR1CYP2C8 | |
| SCHEMBL18646920 | 0.83 | FFAR1 (0.41) | DRD2DRD3CYP11B1CYP11B2EPAS1 | |
| SCHEMBL18646918 | 0.82 | FFAR1 (0.46) | DRD2DRD3EPAS1FFAR1 | |
| SCHEMBL18646919 | 0.82 | FFAR1 (0.43) | DRD2DRD3CYP11B1CYP11B2EPAS1 | |
| SCHEMBL18646744 | 0.82 | FFAR1 (0.43) | DRD2DRD3FFAR1CYP2C8CYP2C9 | |
| SCHEMBL193672 | 0.81 | DRD2 (0.43) | DRD2DRD3CYP11B1CYP11B2EPAS1 | |
| SCHEMBL193673 | 0.81 | DRD2 (0.43) | DRD2DRD3CYP11B1CYP11B2EPAS1 | |
| SCHEMBL18647453 | 0.81 | FFAR1 (0.43) | DRD2DRD3FFAR1CYP2C8CYP2C9 | |
| SCHEMBL18647113 | 0.81 | FFAR1 (0.34) | CYP11B1CYP11B2EPAS1FFAR1CYP2C8 | |
| SCHEMBL18615202 | 0.80 | FFAR1 (0.34) | CYP11B1CYP11B2EPAS1FFAR1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017042121-A1 | [{[2,3-DIHYDRO-1H-INDEN-1-YL]AMINO}-2H,3H-FURO[3,2-B]PYRIDIN-3-YL]ACETIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-03-16 | — | — | WO | disclosed |