Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23084281 | 0.86 | LMNA (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9593487 | 0.85 | LMNA (0.49) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19464670 | 0.81 | MAPT (0.38) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18704817 | 0.81 | TP53 (0.42) | MAPTLMNATP53HTTGPR84 | |
| SCHEMBL14640349 | 0.80 | MAPT (0.42) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18928638 | 0.79 | HTT (0.42) | MAPTLMNATP53HTTGAA | |
| SCHEMBL9593590 | 0.78 | LMNA (0.52) | MAPTLMNATP53HTTCNR1 | |
| SCHEMBL22350765 | 0.77 | MAPT (0.40) | MAPTEPHX2PSEN1PSEN2APH1B | |
| SCHEMBL23251395 | 0.77 | CNR1 (0.37) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3083071 | 0.76 | MEN1 (0.40) | TP53GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598367-B2 | Heterocyclic compounds as bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2017-03-21 | — | — | US | disclosed |