Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 20/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 20/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 20/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 20/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 20/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 20/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7921146 | 0.84 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18649314 | 0.84 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16923575 | 0.82 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9607092 | 0.81 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12141129 | 0.80 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6127821 | 0.80 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22184931 | 0.78 | HCAR1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16914028 | 0.77 | TLR2 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7838053 | 0.72 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3313126 | 0.72 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598437-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP. (US) | 2017-03-21 | — | — | US | disclosed |