Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.67 |
| ▸ | CDK2 | P24941 | 2/20 | 0.67 |
| ▸ | CDK9 | P50750 | 2/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.67 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18645548 | 0.91 | IGF1R (0.59) | IGF1RCCNT1CDK2CDK9CCNE1 | |
| SCHEMBL18649367 | 0.91 | IGF1R (0.80) | IGF1RSYKNTRK1 | |
| SCHEMBL18645550 | 0.87 | IGF1R (0.54) | IGF1RCCNT1CDK2CDK9CCNE1 | |
| SCHEMBL18649369 | 0.86 | IGF1R (0.57) | IGF1RCCNT1CDK2CDK9CCNE1 | |
| SCHEMBL18645552 | 0.83 | IGF1R (0.67) | IGF1RSYKNTRK1 | |
| SCHEMBL18645557 | 0.83 | IGF1R (0.51) | IGF1RCCNT1CDK2CDK9CCNE1 | |
| SCHEMBL18649368 | 0.83 | IGF1R (0.54) | IGF1RCCNT1CDK2CDK9CDK1 | |
| SCHEMBL18645551 | 0.81 | IGF1R (0.68) | IGF1RNTRK1 | |
| SCHEMBL12952410 | 0.81 | CCNT1 (0.75) | CCNT1CDK2CDK9CCNE1SYK | |
| SCHEMBL11932243 | 0.80 | IGF1R (1.00) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598432-B2 | 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents | RIGEL PHARMACEUTICALS, INC. (US) | 2017-03-21 | — | — | US | disclosed |