Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.80 |
| ▸ | SYK | P43405 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18645552 | 0.92 | IGF1R (0.67) | IGF1RSYKNTRK1 | |
| SCHEMBL18649366 | 0.91 | IGF1R (0.67) | IGF1RSYKNTRK1 | |
| SCHEMBL18645551 | 0.90 | IGF1R (0.68) | IGF1RNTRK1 | |
| SCHEMBL11932243 | 0.89 | IGF1R (1.00) | IGF1R | |
| SCHEMBL18645547 | 0.86 | ALK (0.63) | IGF1RSYK | |
| SCHEMBL18649471 | 0.83 | IGF1R (0.77) | IGF1RNTRK1 | |
| SCHEMBL18645553 | 0.83 | IGF1R (0.66) | IGF1RNTRK1 | |
| SCHEMBL18649365 | 0.83 | IGF1R (0.61) | IGF1R | |
| SCHEMBL18645548 | 0.82 | IGF1R (0.59) | IGF1RNTRK1 | |
| SCHEMBL657421 | 0.82 | SYK (1.00) | IGF1RSYKAURKAAURKBNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598432-B2 | 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents | RIGEL PHARMACEUTICALS, INC. (US) | 2017-03-21 | — | — | US | disclosed |