SCHEMBL18650296

SCHEMBL18650296

Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(N=O)CC3)C2)ncn1

nearest known ligand 0.64

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 20/20 0.64
HTR2B P41595 2/20 0.59
KCNH2 Q12809 2/20 0.59
CHRM2 P08172 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2434739 0.86 GHSR (0.72) GHSRHTR2BKCNH2CHRM2
SCHEMBL31529052 0.86 GHSR (0.72) GHSRHTR2BKCNH2CHRM2
SCHEMBL12299415 0.84 GHSR (0.61) GHSRHTR2BKCNH2CHRM2
Hydrochloric Acid SCHEMBL2434802 0.83 GHSR (0.60) GHSRHTR2BKCNH2CHRM2
Hydrochloric Acid SCHEMBL2434223 0.83 GHSR (0.60) GHSRHTR2BKCNH2CHRM2
SCHEMBL16667951 0.82 GHSR (0.67) GHSRHTR2BKCNH2CHRM2
SCHEMBL2440292 0.82 GHSR (0.67) GHSRHTR2BKCNH2CHRM2
SCHEMBL18650608 0.81 GHSR (0.46) GHSRHTR2BKCNH2
SCHEMBL12299414 0.80 GHSR (0.66) GHSRHTR2BKCNH2CHRM2
SCHEMBL12328037 0.79 GHSR (0.65) GHSRHTR2BKCNH2CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017045648-A1 PREPARATION METHOD FOR DEUTERATED COMPOUND 正大天晴药业集团股份有限公司 2017-03-23 WO disclosed