Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 5/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870092 | 0.91 | VEGFA (0.60) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL1868252 | 0.87 | VEGFA (0.57) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL1770233 | 0.86 | VEGFA (0.61) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL1770481 | 0.86 | ALDH1A1 (0.73) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL1867899 | 0.86 | VEGFA (0.59) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL1868736 | 0.86 | VEGFA (0.64) | VEGFAEGLN1ALDH1A1KDM4EKMT2A | |
| SCHEMBL1770324 | 0.85 | KDM4E (0.58) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL272116 | 0.84 | VEGFA (0.85) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL27866629 | 0.83 | VEGFA (0.55) | VEGFAEGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL1770721 | 0.82 | VEGFA (0.69) | VEGFAEGLN1ALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496084-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057121-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |