Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20083937 | 0.77 | EPHX1 (0.39) | — | |
| SCHEMBL2377577 | 0.76 | CHRM2 (0.35) | KDM4ELMNACYP2C19 | |
| SCHEMBL21451469 | 0.76 | — | — | |
| SCHEMBL13082726 | 0.74 | KDM4E (0.36) | KDM4ELMNACYP2C19 | |
| SCHEMBL13936288 | 0.74 | KDM4E (0.31) | KDM4ELMNACYP2C19 | |
| SCHEMBL2377573 | 0.74 | KDM4E (0.31) | KDM4ELMNACYP2C19 | |
| SCHEMBL26821741 | 0.74 | GNAI3 (0.31) | KDM4ELMNACYP2C19 | |
| SCHEMBL20083935 | 0.73 | — | — | |
| SCHEMBL5756962 | 0.73 | — | — | |
| SCHEMBL613348 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020245665-A1 | N-(4-(5-CHLOROPYRIDIN-3-YL)PHENYL)-2-(2-(CYCLOPROPANESULFONAMIDO)PYRIMIDIN-4-YL) BUTANAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | STEP PHARMA S.A.S. (FR) | 2020-12-10 | — | — | WO | disclosed |
| EP-3144311-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVE HAVING HIV REPLICATION-INHIBITING EFFECT | Shionogi & Co., Ltd. (JP) | 2017-03-22 | — | — | EP | disclosed |