Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054435 | 0.83 | SYK (0.48) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL11886701 | 0.83 | SYK (0.54) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL28766687 | 0.83 | SYK (0.48) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL11886704 | 0.82 | SYK (0.47) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL30500895 | 0.81 | SYK (0.60) | SYKSMN1; SMN2LMNACTSSATM | |
| SCHEMBL4252270 | 0.81 | SMN1; SMN2 (0.52) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL13569335 | 0.81 | SMN1; SMN2 (0.52) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL969931 | 0.79 | LMNA (0.51) | SMN1; SMN2LMNAATMHTTMAPT | |
| SCHEMBL20556351 | 0.78 | SYK (0.47) | SYKSMN1; SMN2LMNACTSSCTSL | |
| SCHEMBL9741135 | 0.76 | LMNA (0.50) | SYKSMN1; SMN2LMNACTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595483-B1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2017-03-22 | — | — | EP | disclosed |