Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14881846 | 0.88 | IRAK4 (0.50) | IRAK4PIM1TGFBR1TGFBR2NTRK1 | |
| SCHEMBL18654925 | 0.84 | IRAK4 (0.48) | IRAK4PIM1TGFBR1TGFBR2NTRK1 | |
| SCHEMBL21765944 | 0.84 | IRAK4 (0.48) | IRAK4PIM1TGFBR1TGFBR2NTRK1 | |
| SCHEMBL18654880 | 0.84 | IRAK4 (0.48) | IRAK4PIM1TGFBR1TGFBR2NTRK1 | |
| SCHEMBL21637233 | 0.81 | HTT (0.46) | IRAK4PIM1TGFBR1TGFBR2 | |
| SCHEMBL14897701 | 0.81 | IRAK4 (0.49) | IRAK4NTRK1 | |
| SCHEMBL20355596 | 0.81 | IRAK4 (0.53) | IRAK4PIM1NTRK1NTRK3 | |
| SCHEMBL14897403 | 0.81 | NTRK1 (0.45) | IRAK4TGFBR1TGFBR2NTRK1 | |
| SCHEMBL14896727 | 0.80 | IRAK4 (0.49) | IRAK4PIM1MAP4K4EIF2AK4NTRK1 | |
| SCHEMBL14896942 | 0.80 | IRAK4 (0.49) | IRAK4PIM1EIF2AK4NTRK1SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |