Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14881453 | 0.90 | NTRK1 (0.44) | NTRK1 | |
| SCHEMBL14881595 | 0.83 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL18654582 | 0.81 | IRAK4 (0.48) | NTRK1TGFBR1TGFBR2IRAK4 | |
| SCHEMBL14897739 | 0.80 | NTRK1 (0.46) | NTRK1IRAK4 | |
| SCHEMBL14897003 | 0.80 | LMNA (0.43) | NTRK1IRAK4 | |
| SCHEMBL14881970 | 0.80 | NTRK1 (0.43) | NTRK1IRAK4 | |
| SCHEMBL14881516 | 0.80 | LMNA (0.43) | NTRK1IRAK4 | |
| SCHEMBL14896843 | 0.80 | IRAK4 (0.41) | NTRK1IRAK4 | |
| SCHEMBL14896812 | 0.79 | NTRK1 (0.41) | NTRK1IRAK4 | |
| SCHEMBL14897267 | 0.79 | NTRK1 (0.46) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059587-A1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |