Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 11/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896824 | 0.93 | SCN10A (0.43) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14896837 | 0.90 | RIPK1 (0.41) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL16193146 | 0.88 | SCN10A (0.40) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14896733 | 0.88 | RIPK1 (0.40) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14897347 | 0.86 | RIPK1 (0.44) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14897090 | 0.86 | RIPK1 (0.42) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL16193152 | 0.84 | RIPK1 (0.42) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL16193151 | 0.83 | MPL (0.42) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14896947 | 0.83 | EPHB3 (0.40) | SCN10AABL1 | |
| SCHEMBL14896757 | 0.83 | NAMPT (0.45) | SCN10ASCN5ASCN9ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |