Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654754 | 0.83 | NTRK1 (0.38) | IRAK4NTRK1 | |
| SCHEMBL14897195 | 0.81 | IRAK4 (0.43) | SYKARKCNH2RXFP1IRAK4 | |
| SCHEMBL18654799 | 0.78 | PIM1 (0.40) | AAK1RXFP1IRAK4NTRK1DYRK1A | |
| SCHEMBL18655071 | 0.73 | GBA1 (0.33) | ARKCNH2MAPTCSNK1EALDH1A1 | |
| SCHEMBL16193131 | 0.72 | IRAK4 (0.42) | ARKCNH2IRAK4NTRK1DYRK1A | |
| SCHEMBL14897190 | 0.71 | PTPN11 (0.46) | SYKRXFP1IRAK4KMT2ANTRK1 | |
| SCHEMBL18655322 | 0.70 | GSK3B (0.38) | ARKCNH2RXFP1IRAK4NTRK1 | |
| SCHEMBL14897792 | 0.70 | IRAK4 (0.45) | ARKCNH2RXFP1IRAK4NTRK1 | |
| SCHEMBL14897193 | 0.69 | PTPN11 (0.47) | IRAK4DYRK1ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL18655324 | 0.68 | KDM4E (0.40) | RXFP1IRAK4DYRK1ACSNK1EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |