Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.30 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14897813 | 0.80 | KIF18A (0.38) | GBA1CACNA1HKIF18A | |
| SCHEMBL18655168 | 0.77 | AADAT (0.32) | — | |
| SCHEMBL14897426 | 0.76 | KIF18A (0.38) | CSNK1ECACNA1HSMN1; SMN2KIF18A | |
| SCHEMBL18654755 | 0.73 | SYK (0.35) | ARKCNH2CSNK1EALDH1A1MAPT | |
| SCHEMBL14896660 | 0.71 | GBA1 (0.41) | GBA1KCNH2CSNK1ECACNA1HALDH1A1 | |
| SCHEMBL16193131 | 0.71 | IRAK4 (0.42) | ARKCNH2CACNA1HKIF18A | |
| SCHEMBL14881761 | 0.68 | CLK2 (0.46) | SMN1; SMN2KIF18A | |
| SCHEMBL14897792 | 0.65 | IRAK4 (0.45) | ARKCNH2 | |
| SCHEMBL18654654 | 0.64 | SMN1; SMN2 (0.41) | CSNK1EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14897385 | 0.63 | GLS (0.39) | KCNH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |