Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14897027 | 1.00 | NTRK1 (0.43) | NTRK1IRAK4 | |
| SCHEMBL14882121 | 0.88 | NTRK1 (0.44) | NTRK1IRAK4 | |
| SCHEMBL14882125 | 0.88 | NTRK1 (0.44) | NTRK1IRAK4 | |
| SCHEMBL14897293 | 0.83 | IRAK4 (0.49) | NTRK1IRAK4 | |
| SCHEMBL14897269 | 0.83 | IRAK4 (0.49) | NTRK1IRAK4 | |
| SCHEMBL14896935 | 0.82 | NTRK1 (0.46) | NTRK1IRAK4 | |
| SCHEMBL20098873 | 0.81 | NTRK1 (0.38) | NTRK1IRAK4 | |
| SCHEMBL22084290 | 0.79 | NTRK1 (0.44) | NTRK1IRAK4 | |
| SCHEMBL22083694 | 0.78 | NTRK1 (0.45) | NTRK1IRAK4 | |
| SCHEMBL14897161 | 0.77 | IRAK4 (0.49) | NTRK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |