Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896950 | 0.86 | TGFBR1 (0.53) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14896948 | 0.82 | SCN10A (0.45) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14897307 | 0.79 | TGFBR1 (0.46) | TGFBR1SCN10ARIPK1KMT2AFYN | |
| SCHEMBL14897191 | 0.78 | TGFBR1 (0.50) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14896829 | 0.77 | TGFBR1 (0.45) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14896687 | 0.76 | TGFBR1 (0.44) | TGFBR1SCN10AKMT2AFYNSMN1; SMN2 | |
| SCHEMBL14896694 | 0.76 | FYN (0.46) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14896786 | 0.76 | TGFBR1 (0.47) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14897001 | 0.76 | TGFBR1 (0.47) | TGFBR1SCN10ARIPK1FYNDYRK1A | |
| SCHEMBL14896997 | 0.75 | TGFBR1 (0.44) | TGFBR1SCN10ARIPK1FYNDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |