SCHEMBL18656304

SCHEMBL18656304

COc1ccc(-c2cc(=O)c3c(O)cc(OP(OCc4ccccc4)OCc4ccccc4)cc3o2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.67
CYP19A1 P11511 2/20 0.67
MAPT P10636 5/20 0.65
ABCB1 P08183 4/20 0.65
NPC1 O15118 3/20 0.65
CYP3A4 P08684 3/20 0.65
CYP2C9 P11712 3/20 0.65
CYP2C19 P33261 3/20 0.65
ABCG2 Q9UNQ0 2/20 0.65
TSHR P16473 1/20 0.65
FLT3 P36888 3/20 0.64
MEN1 O00255 3/20 0.64
KMT2A Q03164 3/20 0.64
CYP1A1 P04798 3/20 0.64
CYP1A2 P05177 3/20 0.64
IP6K2 Q9UHH9 2/20 0.64
CDK8 P49336 2/20 0.64
RAB9A P51151 2/20 0.64
ALDH1A1 P00352 2/20 0.64
TP53 P04637 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16977197 0.82 MAOB (0.81) MAOBCYP19A1MAPTABCB1NPC1
Apigenin Dimethylether SCHEMBL29392759 0.81 MAOB (1.00) MAOBCYP19A1MAPTABCB1NPC1
Apigenin Dimethylether SCHEMBL1176691 0.81 MAOB (1.00) MAOBCYP19A1MAPTABCB1NPC1
SCHEMBL8305040 0.81 MAPT (0.73) MAOBCYP19A1MAPTABCB1NPC1
SCHEMBL16977186 0.81 MAOB (0.65) MAOBCYP19A1MAPTABCB1NPC1
Techtochrysin SCHEMBL249043 0.80 MAPT (1.00) MAOBCYP19A1MAPTABCB1NPC1
Techtochrysin SCHEMBL29494561 0.80 MAPT (1.00) MAOBCYP19A1MAPTABCB1NPC1
SCHEMBL28762810 0.80 MAPT (0.79) MAOBCYP19A1MAPTABCB1NPC1
Acacetin SCHEMBL107712 0.79 CYP1B1 (1.00) MAOBCYP19A1MAPTABCB1NPC1
Acacetin SCHEMBL29387049 0.79 CYP1B1 (1.00) MAOBCYP19A1MAPTABCB1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2902399-B1 Water-soluble derivatives and prodrugs of acacetin and methods of making and using thereof VERSITECH LTD (CN) 2017-03-22 EP disclosed