Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18656782 | 0.82 | MEN1 (0.33) | DYRK1ALRRK2SRC | |
| SCHEMBL18656762 | 0.74 | DYRK1A (0.58) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL22677021 | 0.73 | DYRK1A (0.56) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL29407793 | 0.68 | LRRK2 (0.54) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL22658714 | 0.68 | LRRK2 (0.54) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL30582621 | 0.67 | DYRK1A (1.00) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL26110102 | 0.67 | DYRK1A (1.00) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL868932 | 0.67 | FLT3 (0.42) | DYRK1ALRRK2ADORA2AADORA1ADORA2B | |
| SCHEMBL18341978 | 0.65 | MEN1 (0.35) | DYRK1AADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL18656780 | 0.65 | MEN1 (0.35) | DYRK1AADORA2AADORA1ADORA2BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046738-A1 | TRIAZOLONE COMPOUNDS AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-23 | — | — | WO | disclosed |