Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18656953 | 0.89 | PTGS1 (0.40) | KMT2AMAPTMEN1USP2GAA | |
| SCHEMBL10159127 | 0.89 | PTGS1 (0.40) | KMT2AMAPTMEN1USP2GAA | |
| SCHEMBL10159165 | 0.89 | PTGS1 (0.40) | KMT2AMAPTMEN1USP2GAA | |
| SCHEMBL10159253 | 0.89 | PTGS1 (0.40) | KMT2AMAPTMEN1USP2GAA | |
| SCHEMBL18656913 | 0.83 | KMT2A (0.51) | KMT2AMAPTMEN1USP2GAA | |
| SCHEMBL18250133 | 0.82 | PTGS1 (0.38) | KMT2AL3MBTL1ALDH1A1PKM | |
| SCHEMBL18250129 | 0.82 | PTGS1 (0.38) | KMT2AL3MBTL1ALDH1A1PKM | |
| SCHEMBL18250126 | 0.82 | PTGS1 (0.38) | KMT2AL3MBTL1ALDH1A1PKM | |
| SCHEMBL18656955 | 0.77 | MAPT (0.50) | KMT2AMAPTMEN1USP2GAA | |
| SCHEMBL18656967 | 0.76 | MAPT (0.49) | KMT2AMAPTMEN1USP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144299-A1 | PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Cambria Pharmaceuticals, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |