Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10159299 | 0.89 | OPRM1 (0.40) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL10159225 | 0.89 | OPRM1 (0.40) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL10159267 | 0.89 | OPRM1 (0.40) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL10159084 | 0.86 | MAPT (0.66) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL18656937 | 0.83 | KMT2A (0.70) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL18656864 | 0.78 | MAPT (0.40) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL18656873 | 0.77 | KMT2A (0.44) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL13067890 | 0.75 | MAPT (0.47) | MAPTKMT2AMEN1HSD17B10GAA | |
| SCHEMBL10159296 | 0.75 | MAPT (0.33) | MAPTKMT2AMEN1HSD17B10USP2 | |
| SCHEMBL10159133 | 0.75 | MAPT (0.33) | MAPTKMT2AMEN1HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144299-A1 | PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Cambria Pharmaceuticals, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |