Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 4/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10158844 | 0.89 | KMT2A (0.49) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL10158875 | 0.89 | KMT2A (0.49) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL10158862 | 0.89 | KMT2A (0.49) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL18656956 | 0.89 | KMT2A (0.49) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL10159473 | 0.89 | KMT2A (0.49) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL18656913 | 0.84 | KMT2A (0.51) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL10158776 | 0.84 | KMT2A (1.00) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL10159405 | 0.84 | KMT2A (0.70) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL18656955 | 0.83 | MAPT (0.50) | KMT2AMEN1MAPTGAAHSD17B10 | |
| SCHEMBL18656967 | 0.82 | MAPT (0.49) | KMT2AMEN1MAPTGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144299-A1 | PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Cambria Pharmaceuticals, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |