Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 9/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1875007 | 0.76 | ADORA1 (0.55) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL1871234 | 0.74 | ADORA1 (0.47) | ADORA1ADORA3ADORA2ATNK2ADORA2B | |
| SCHEMBL1861450 | 0.72 | ADORA1 (0.49) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL1869254 | 0.72 | ADORA1 (0.40) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL1869240 | 0.72 | ADORA1 (0.38) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL1875802 | 0.70 | ADORA1 (0.44) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL1871069 | 0.68 | ADORA1 (0.54) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL1867187 | 0.68 | ADORA2A (0.34) | ADORA1ADORA2AADORA2B | |
| SCHEMBL1871663 | 0.64 | TP53 (0.45) | ADORA1TP53MAPT | |
| SCHEMBL1870822 | 0.64 | ADORA1 (0.55) | ADORA1ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | claimed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |