Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 5/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18658595 | 0.88 | KCNH2 (0.66) | CHRM3KCNH2DRD2DRD3RORC | |
| SCHEMBL19381140 | 0.80 | DRD2 (0.51) | CHRM3KCNH2DRD2DRD3RORC | |
| SCHEMBL20614208 | 0.79 | KCNH2 (0.67) | KCNH2DRD2DRD3RORCDRD1 | |
| SCHEMBL17294412 | 0.79 | KCNH2 (0.62) | CHRM3KCNH2RORC | |
| SCHEMBL17294414 | 0.79 | KCNH2 (0.62) | CHRM3KCNH2RORC | |
| SCHEMBL20614218 | 0.79 | KCNH2 (0.55) | KCNH2DRD2DRD3RORCDRD1 | |
| SCHEMBL17182367 | 0.77 | CHRM3 (0.53) | CHRM3KCNH2DRD2DRD3RORC | |
| SCHEMBL15777307 | 0.77 | CHRM3 (0.53) | CHRM3KCNH2DRD2DRD3RORC | |
| SCHEMBL17295853 | 0.77 | KCNH2 (0.58) | CHRM3KCNH2RORC | |
| SCHEMBL15783949 | 0.77 | KCNH2 (0.71) | CHRM3KCNH2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3219711-A1 | MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | Glaxo Group Limited (GB) | 2017-09-20 | — | — | EP | disclosed |
| EP-2928885-B1 | MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2017-03-22 | — | — | EP | disclosed |