Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30638198 | 0.85 | LRRK2 (0.37) | LRRK2GRIN1GRIN2BGSK3BPIK3CA | |
| SCHEMBL30154553 | 0.83 | LRRK2 (0.53) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18606314 | 0.83 | LRRK2 (0.51) | LRRK2GRIN1GRIN2BPIK3CDPIK3CA | |
| SCHEMBL18606424 | 0.83 | LRRK2 (0.53) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL23934992 | 0.82 | GRIN1 (0.39) | LRRK2GRIN1GRIN2B | |
| SCHEMBL18659040 | 0.81 | LRRK2 (0.37) | LRRK2GRIN1GRIN2BCSNK1A1CSNK1D | |
| SCHEMBL18659043 | 0.81 | GRIN1 (0.40) | LRRK2GRIN1GRIN2BCSNK1A1CSNK1D | |
| SCHEMBL18606456 | 0.79 | LRRK2 (0.52) | LRRK2GRIN1GRIN2BCSNK1A1CSNK1D | |
| SCHEMBL18606528 | 0.79 | LRRK2 (0.36) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18659010 | 0.78 | LRRK2 (0.42) | LRRK2GRIN1GRIN2BIRAK4PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111051304-B | Imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2022-12-27 | — | — | CN | disclosed |
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2017046675-A1 | NOVEL IMIDAZO [4,5-C] QUINOLINE AND IMIDAZO [4,5-C][1,5] NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-03-23 | — | — | WO | disclosed |