Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18606424 | 1.00 | LRRK2 (0.53) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18659010 | 0.86 | LRRK2 (0.42) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18606456 | 0.85 | LRRK2 (0.52) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18658935 | 0.84 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL18658940 | 0.84 | GRIN2B (0.41) | LRRK2GRIN1GRIN2B | |
| SCHEMBL18606314 | 0.83 | LRRK2 (0.51) | LRRK2GRIN1GRIN2B | |
| SCHEMBL18658680 | 0.83 | LRRK2 (0.49) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18606528 | 0.83 | LRRK2 (0.36) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18659043 | 0.83 | GRIN1 (0.40) | LRRK2GRIN1GRIN2B | |
| SCHEMBL30154964 | 0.82 | GRIN2B (0.38) | LRRK2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111051304-B | Imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2022-12-27 | — | — | CN | claimed |
| CN-111051304-B | Imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2022-12-27 | — | — | CN | disclosed |