Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19696488 | 0.82 | KARS1 (0.54) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL19018793 | 0.81 | CYP3A4 (0.57) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL20866213 | 0.81 | CYP3A4 (0.57) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL19696490 | 0.79 | KARS1 (0.53) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL9745072 | 0.78 | CYP3A4 (0.57) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL6319704 | 0.78 | KARS1 (0.56) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL18431217 | 0.75 | TDP1 (0.76) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL14496633 | 0.75 | TDP1 (0.76) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL28552138 | 0.73 | KARS1 (0.66) | CYP3A4KARS1MEN1KMT2ATSHR | |
| SCHEMBL6280790 | 0.72 | CYP3A4 (0.72) | CYP3A4KARS1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170079936-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170079936-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | PCNA, DERA, TOP2A | CYP3A4 4644/4885KARS1 2629/4885MEN1 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.