Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18664066 | 0.95 | TLR9 (0.36) | PARP14TLR9TLR8TLR7GRM4 | |
| SCHEMBL18639868 | 0.86 | PARP14 (0.37) | PARP14TLR9TLR8TLR7ALK | |
| SCHEMBL18664070 | 0.82 | DRD4 (0.35) | PARP14HRH3 | |
| SCHEMBL18639788 | 0.81 | HRH3 (0.36) | PARP14TLR9TLR8TLR7ALK | |
| SCHEMBL18639930 | 0.80 | PARP14 (0.40) | PARP14TLR9TLR8TLR7HRH3 | |
| SCHEMBL18640060 | 0.79 | TDP1 (0.40) | PARP14 | |
| SCHEMBL18640015 | 0.79 | MAP3K12 (0.37) | PARP14TLR9TLR8TLR7ALK | |
| SCHEMBL18639984 | 0.78 | TLR9 (0.39) | PARP14TLR9TLR8TLR7ALK | |
| SCHEMBL18639892 | 0.76 | GPR119 (0.45) | PARP14 | |
| SCHEMBL18664092 | 0.75 | P2RY1 (0.39) | PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |