Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18736144 | 0.81 | TSHR (0.40) | TSHRKDM4ELMNASLC6A5KDM4A | |
| SCHEMBL21155013 | 0.79 | TSHR (0.70) | TSHRKDM4ELMNAMEN1HPGD | |
| SCHEMBL14978144 | 0.78 | TSHR (0.42) | TSHRKDM4ELMNAMEN1KMT2A | |
| SCHEMBL22112002 | 0.78 | SLC6A5 (0.37) | TSHRSLC6A5KDM4AHIF1ATET2 | |
| SCHEMBL23723856 | 0.77 | TSHR (0.36) | TSHRKDM4ELMNASLC6A5KDM4A | |
| SCHEMBL13785356 | 0.76 | TSHR (0.40) | TSHRKDM4ELMNASLC6A5KDM4A | |
| SCHEMBL19509699 | 0.76 | TSHR (0.37) | TSHRKDM4ELMNASLC6A5KDM4A | |
| SCHEMBL21286080 | 0.76 | TSHR (0.41) | TSHRKDM4ELMNAMEN1HPGD | |
| SCHEMBL15592334 | 0.75 | RECQL (0.41) | TSHRHPGDSLC6A5KDM4AHIF1A | |
| SCHEMBL16392928 | 0.74 | TSHR (0.41) | TSHRKDM4ELMNAMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017048843-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ALNYLAM PHARMACEUTICALS, INC. (US) | 2017-03-23 | — | — | WO | disclosed |