Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 10/20 | 0.65 |
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1865558 | 0.90 | VEGFA (0.65) | VEGFAEGLN1ALDH1A1MAPTTHRB | |
| SCHEMBL24255673 | 0.89 | VEGFA (0.68) | VEGFAEGLN1ALDH1A1MAPTTHRB | |
| SCHEMBL272076 | 0.88 | VEGFA (0.85) | VEGFAEGLN1ALDH1A1 | |
| SCHEMBL1868340 | 0.86 | VEGFA (0.63) | VEGFAEGLN1ALDH1A1L3MBTL1HTR6 | |
| SCHEMBL1770489 | 0.86 | VEGFA (0.66) | VEGFAEGLN1ALDH1A1 | |
| SCHEMBL1865127 | 0.85 | VEGFA (0.62) | VEGFAEGLN1ALDH1A1MAPTTHRB | |
| SCHEMBL1770477 | 0.84 | VEGFA (0.66) | VEGFAEGLN1ALDH1A1MAPTGAA | |
| SCHEMBL1770264 | 0.83 | VEGFA (0.64) | VEGFAEGLN1ALDH1A1GAA | |
| SCHEMBL28799956 | 0.83 | VEGFA (0.57) | VEGFAEGLN1ALDH1A1MAPTTHRB | |
| SCHEMBL27882886 | 0.83 | VEGFA (0.59) | VEGFAEGLN1ALDH1A1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |