Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 8/20 | 0.63 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866840 | 0.91 | VEGFA (0.63) | VEGFAEGLN1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL271566 | 0.88 | VEGFA (0.65) | VEGFAEGLN1ALDH1A1KMT2A | |
| SCHEMBL1770508 | 0.87 | VEGFA (0.64) | VEGFAEGLN1L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL271286 | 0.87 | EGLN1 (0.67) | VEGFAEGLN1HTR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL1870466 | 0.87 | VEGFA (0.60) | VEGFAEGLN1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1866671 | 0.86 | VEGFA (0.65) | VEGFAEGLN1L3MBTL1HTR6ALDH1A1 | |
| SCHEMBL272076 | 0.86 | VEGFA (0.85) | VEGFAEGLN1CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL1770106 | 0.86 | VEGFA (0.56) | VEGFAEGLN1L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL272197 | 0.85 | VEGFA (0.61) | VEGFAEGLN1CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL27866622 | 0.85 | VEGFA (0.55) | VEGFAEGLN1HTR6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |