Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tretinoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA known ✓ | P19793 | 5/20 | 1.00 |
| ▸ | RARA known ✓ | P10276 | 4/20 | 1.00 |
| ▸ | RARB known ✓ | P10826 | 4/20 | 1.00 |
| ▸ | RARG known ✓ | P13631 | 4/20 | 1.00 |
| ▸ | RXRB known ✓ | P28702 | 2/20 | 1.00 |
| ▸ | RXRG known ✓ | P48443 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 4/20 | 1.00 |
| ▸ | APP | P05067 | 4/20 | 1.00 |
| ▸ | SNCA | P37840 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | RORC | P51449 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tretinoin SCHEMBL3146 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Isotretinoin SCHEMBL9123793 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Tretinoin SCHEMBL8399912 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Tretinoin SCHEMBL7846921 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Tretinoin SCHEMBL24982760 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Isotretinoin SCHEMBL38299 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Tretinoin SCHEMBL24982761 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Alitretinoin SCHEMBL5331051 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Isotretinoin SCHEMBL20603086 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA | |
| Tretinoin SCHEMBL445176 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4RXRARARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7398 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125650-A1 | METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES | TRAILHEAD BIOSYSTEMS INC (US) | 2026-05-07 | — | — | US | claimed |
| US-12589189-B2 | Use of retinoic acid receptor (RAR) agonists for reversing, preventing, or delaying calcification of aortic valve | INSERM (INSTITUTE NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE) (FR) | 2026-03-31 | — | — | US | claimed |
| EP-4037672-B1 | RETINOIC ACID RECEPTOR (RAR) AGONISTS FOR REVERSING, PREVENTING, OR DELAYING CALCIFICATION OF AORTIC VALVE | INST NAT SANTE RECH MED (FR) | 2026-03-11 | — | — | EP | claimed |
| US-12571046-B2 | Methods of detecting and treating multiple system atrophy | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2026-03-10 | — | — | US | claimed |
| US-12528776-B2 | Composition and method for treating dermatological disorders using retinamides | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2026-01-20 | — | — | US | claimed |
| US-20250305010-A1 | LIPID COMPOSITIONS AND METHODS OF PRODUCING SAME | WILK TECHNOLOGIES INTERNATIONAL LTD. (IL) | 2025-10-02 | — | — | US | claimed |
| US-20250304916-A1 | METHODS AND COMPOSITIONS FOR GENERATING VASCULAR LEPTOMENINGEAL CELLS | TRAILHEAD BIOSYSTEMS INC (US) | 2025-10-02 | — | — | US | claimed |
| EP-4591859-A1 | LIPID NANOPARTICLE, PREPARATION METHOD THEREFOR, AND USE THEREOF | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2025-07-30 | — | — | EP | claimed |
| US-20250213496-A1 | LIPID NANOPARTICLES AND PREPARATION METHODS AND USE THEREOF | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2025-07-03 | — | — | US | claimed |
| US-20240299329-A1 | PRECURSOR COMPOUNDS FOR PROVIDING RETINOIDS OF THE VATAMIN A5 PATHWAY AND USES THEREOF | UNIV OF DEBRECEN (HU) | 2024-09-12 | — | — | US | claimed |
| EP-0633773-A1 | METHOD OF TREATMENT OF HYPERPIGMENTATION IN BLACK SKIN WITH RETINOIC ACID AND METHOD OF LIGHTENING BLACK SKIN WITH RETINOIC ACID | The Regents of The University of Michigan (US) | 1995-01-18 | — | — | EP | claimed |
| EP-0625045-A1 | METHODS OF TREATING INFLAMMATORY DERMATOSES | Kligman, Albert M. (US) | 1994-11-23 | — | — | EP | claimed |
| EP-0633773-A4 | METHOD OF TREATMENT OF HYPERPIGMENTATION IN BLACK SKIN WITH RETINOIC ACID AND METHOD OF LIGHTENING BLACK SKIN WITH RETINOIC ACID. | UNIV MICHIGAN (US) | 1994-11-09 | — | — | EP | claimed |
| EP-0617614-A1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1994-10-05 | — | — | EP | claimed |
| CN-1080525-A | pharmaceutical composition | HOFFMANN LA ROCHE (CH) | 1994-01-12 | — | — | CN | claimed |
| WO-1993019743-A1 | METHOD OF TREATMENT OF HYPERPIGMENTATION IN BLACK SKIN WITH RETINOIC ACID AND METHOD OF LIGHTENING BLACK SKIN WITH RETINOIC ACID | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1993-10-14 | — | — | WO | claimed |
| WO-1993019729-A1 | RETINOIC ACID AS A SKIN TANNING AGENT IN PERSONS OF LIGHT SKIN COLOR | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1993-10-14 | — | — | WO | claimed |
| WO-1993015740-A1 | METHODS OF TREATING INFLAMMATORY DERMATOSES | KLIGMAN ALBERT M (US) | 1993-08-19 | — | — | WO | claimed |
| WO-1993011755-A1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1993-06-24 | — | — | WO | claimed |
| US-5219888-A | Increasing plasma high density lipoprotein levels | AMERICAN CYANAMID COMPANY (US) | 1993-06-15 | — | — | US | claimed |