Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CEL | P19835 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870270 | 1.00 | CYP11B2 (0.35) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1859471 | 1.00 | CYP11B2 (0.35) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1864372 | 0.98 | SLC6A2 (0.35) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1860311 | 0.93 | CYP2D6 (0.32) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL455761 | 0.88 | POLB (0.31) | — | |
| SCHEMBL778084 | 0.80 | CYP11B2 (0.46) | CYP11B2KMOACMSDKMT2ATDP1 | |
| SCHEMBL3786509 | 0.78 | CYP11B2 (0.39) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL778085 | 0.77 | HDAC8 (0.43) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7418278 | 0.76 | TSHR (0.40) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3787031 | 0.75 | SLC6A2 (0.38) | CYP11B2KMOSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939509-B2 | Partial and full agonists of A1 adenosine receptors | GILEAD SCIENCES, INC. (US) | 2011-05-10 | — | — | US | disclosed |