Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12669048 | 0.91 | BRAF (0.35) | NR1I2BRAF | |
| SCHEMBL12230879 | 0.83 | BRAF (0.34) | NR1I2BRAF | |
| SCHEMBL1873056 | 0.81 | BRAF (0.32) | NR1I2BRAF | |
| SCHEMBL12669232 | 0.80 | BRAF (0.40) | NR1I2BRAF | |
| SCHEMBL1875099 | 0.79 | BRAF (0.38) | NR1I2BRAF | |
| SCHEMBL1867781 | 0.79 | BRAF (0.32) | NR1I2BRAF | |
| SCHEMBL1873258 | 0.79 | MEN1 (0.33) | — | |
| SCHEMBL1126967 | 0.78 | AR (0.43) | — | |
| SCHEMBL12230874 | 0.78 | BRAF (0.37) | NR1I2BRAF | |
| SCHEMBL26923145 | 0.78 | BRAF (0.41) | NR1I2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |