Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602720 | 0.83 | ALDH1A1 (0.59) | KMT2ATSHRPOLBSMN1; SMN2MEN1 | |
| SCHEMBL29158183 | 0.78 | GPBAR1 (0.59) | KMT2ATSHRPOLBSMN1; SMN2MEN1 | |
| SCHEMBL29158182 | 0.78 | GPBAR1 (0.59) | KMT2ATSHRPOLBSMN1; SMN2MEN1 | |
| SCHEMBL16350192 | 0.75 | TSHR (0.62) | KMT2ATSHRSMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL11059283 | 0.75 | KMT2A (0.57) | KMT2ATSHRSMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL12640683 | 0.74 | CYP19A1 (0.62) | KMT2ATSHRPOLBSMN1; SMN2GAA | |
| SCHEMBL4510150 | 0.74 | CHRM2 (0.52) | KMT2APOLBMEN1ALDH1A1NPSR1 | |
| SCHEMBL41712 | 0.74 | GSK3B (0.61) | KMT2ATSHRSMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL5969377 | 0.73 | ALDH1A1 (0.50) | KMT2ATSHRPOLBSMN1; SMN2MEN1 | |
| SCHEMBL31030081 | 0.73 | KMT2A (0.58) | KMT2ATSHRSMN1; SMN2MEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |