Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | UCHL3 | P15374 | 2/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18669075 | 0.90 | GRM5 (0.49) | HPGDGRM5UCHL3UCHL1ALDH1A1 | |
| SCHEMBL18668938 | 0.88 | MEN1 (0.43) | HPGDUSP2GRM5SMN1; SMN2ALDH1A1 | |
| SCHEMBL18669027 | 0.87 | GRM5 (0.50) | HPGDGRM5UCHL3UCHL1ALDH1A1 | |
| SCHEMBL18668861 | 0.86 | GRM5 (0.47) | HPGDGRM5MAPT | |
| SCHEMBL18669220 | 0.85 | HPGD (0.45) | HPGDUSP2SMN1; SMN2UCHL3UCHL1 | |
| SCHEMBL18669068 | 0.80 | GRM5 (0.43) | HPGDGRM5MAPT | |
| SCHEMBL18669061 | 0.79 | SMN1; SMN2 (0.46) | HPGDGRM5SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL18669189 | 0.75 | MAPT (0.43) | HPGDSMN1; SMN2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL18669181 | 0.74 | AHR (0.43) | HPGDGRM5SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL18669089 | 0.73 | KDM4E (0.67) | HPGDGRM5SMN1; SMN2UCHL3UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |