Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.39 |
| ▸ | CCR9 | P51686 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18668938 | 0.88 | MEN1 (0.43) | GRM5MAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL18669061 | 0.88 | SMN1; SMN2 (0.46) | GRM5RPS6KA2CYP1A2CYP2C19MAPT | |
| SCHEMBL18669027 | 0.86 | GRM5 (0.50) | AHRGRM5MAPTHPGDALDH1A1 | |
| SCHEMBL18669196 | 0.81 | KDM4E (0.54) | CHRM5CHRM3RPS6KA2ACHETRAP1 | |
| SCHEMBL18669233 | 0.79 | CHRM5 (0.50) | GRM5CHRM5CHRM3CYP1A2CYP2C19 | |
| SCHEMBL18669229 | 0.79 | AHR (0.47) | AHRCYP1A2ACHEMAOAMAPT | |
| SCHEMBL18669039 | 0.78 | SMN1; SMN2 (0.57) | AHRRPS6KA2ACHEMAOAMAPT | |
| SCHEMBL18669206 | 0.76 | CA1 (0.52) | GRM5CHRM5CHRM3CYP1A2CYP2C9 | |
| SCHEMBL18668861 | 0.75 | GRM5 (0.47) | GRM5MAPTHPGDKDM4E | |
| SCHEMBL18669093 | 0.74 | HPGD (0.52) | GRM5MAPTSMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |