Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.36 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.36 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.36 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | MSN | P26038 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | UBE2I | P63279 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955892 | 0.75 | PARP1 (0.54) | PARP1 | |
| SCHEMBL20822490 | 0.72 | PARP1 (0.43) | PARP1CYP11B1CYP11B2 | |
| SCHEMBL457994 | 0.72 | HTR2C (0.42) | PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL28793931 | 0.72 | PARP1 (0.49) | PARP1HSPA1AHSPA8CD44MSN | |
| SCHEMBL28227059 | 0.71 | PARP1 (0.37) | PARP1HSPA1AHSPA8CD44MSN | |
| SCHEMBL7674061 | 0.71 | PARP1 (0.39) | PARP1HSPA1AHSPA8CD44MSN | |
| SCHEMBL4359674 | 0.70 | KDM4E (0.45) | PARP1KDM4E | |
| SCHEMBL3809376 | 0.70 | HTR2C (0.59) | PARP1 | |
| SCHEMBL1873751 | 0.69 | GBA1 (0.43) | PARP1CYP11B1CYP11B2HSPA1AHSPA8 | |
| SCHEMBL4141787 | 0.69 | KDM4E (0.48) | PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353171-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDES AND ANALOGUES AS INSECTICIDES | Syngenta Participations AG (CH) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017050922-A1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDES AND ANALOGUES AS INSECTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-03-30 | — | — | WO | disclosed |