SCHEMBL4359674

SCHEMBL4359674

Cc1c(C(N)=O)cccc1C1CCCC1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
MAPT P10636 1/20 0.45
KMT2A Q03164 1/20 0.45
PARP1 P09874 11/20 0.43
CYP2D6 P10635 1/20 0.42
CYP2B6 P20813 1/20 0.42
HTR2C P28335 2/20 0.40
CD38 P28907 2/20 0.40
POLB P06746 1/20 0.40
HTT P42858 1/20 0.40
ESR2 Q92731 1/20 0.40
TP53 P04637 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27003074 0.98 KDM4E (0.48) KDM4EMEN1MAPTKMT2APARP1
SCHEMBL4141787 0.98 KDM4E (0.48) KDM4EMEN1MAPTKMT2APARP1
SCHEMBL457994 0.93 HTR2C (0.42) KDM4EMAPTPARP1CYP2D6CYP2B6
SCHEMBL20822490 0.86 PARP1 (0.43) PARP1HTR2CSLC6A2SLC6A4SLC6A3
SCHEMBL3809376 0.86 HTR2C (0.59) PARP1HTR2C
Hydrochloric Acid SCHEMBL27587929 0.84 HTR2C (0.60) PARP1HTR2C
SCHEMBL161226 0.82 KDM4E (0.50) KDM4EMEN1MAPTKMT2APARP1
SCHEMBL28793931 0.82 PARP1 (0.49) PARP1HTR2C
SCHEMBL30100529 0.81 KDM4E (0.58) KDM4EMEN1MAPTKMT2APARP1
SCHEMBL1990041 0.81 KDM4E (0.50) KDM4EMEN1MAPTKMT2APARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1611109-A4 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF TAISHO PHARMACEUTICAL CO LTD (JP) 2009-06-24 EP claimed
JP-2006522109-A 2006-09-28 JP claimed
EP-1611109-A1 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF TAISHO PHARMACEUTICAL CO., LTD (JP) 2006-01-04 EP claimed
WO-2004087680-A1 NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF TAISHO PHARMACEUTICAL CO., LTD. (JP) 2004-10-14 WO claimed
US-7126027-B2 N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives AKZO NOBEL N.V. (NL) 2006-10-24 US disclosed