Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20342497 | 0.86 | UHRF1 (0.46) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL14670941 | 0.86 | UHRF1 (0.46) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL13991779 | 0.86 | UHRF1 (0.46) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL18879376 | 0.86 | KDM4E (0.43) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL19003624 | 0.83 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL4719814 | 0.80 | UHRF1 (0.41) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL19853069 | 0.80 | F2RL1 (0.34) | ALDH1A1HPGD | |
| SCHEMBL19726829 | 0.80 | UHRF1 (0.41) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL21185561 | 0.80 | NOS3 (0.47) | KDM4ENOS2NOS3NOS1SMN1; SMN2 | |
| SCHEMBL17827971 | 0.79 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9605003-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-03-28 | — | — | US | disclosed |