Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21024134 | 0.71 | SLC22A12 (0.36) | KDRPDPK1PLK4CHEK1AURKA | |
| SCHEMBL19413059 | 0.71 | KDM4E (0.36) | ALDH1A1HPGDSMN1; SMN2KDRPDPK1 | |
| SCHEMBL19170570 | 0.70 | HSP90AB1 (0.31) | — | |
| SCHEMBL13266980 | 0.68 | KDM4E (0.46) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL2616447 | 0.67 | KDM4E (0.52) | ALDH1A1HPGDKDRPDPK1PLK4 | |
| SCHEMBL20227355 | 0.67 | ITK (0.34) | ALDH1A1HPGDKDRPDPK1PLK4 | |
| SCHEMBL22308523 | 0.67 | GRM4 (0.34) | KDRPDPK1PLK4CHEK1AURKA | |
| SCHEMBL762334 | 0.64 | PARP1 (0.46) | MEN1ALDH1A1PRNPMAPTHPGD | |
| SCHEMBL21888896 | 0.63 | GRM4 (0.39) | GRM4 | |
| SCHEMBL25216340 | 0.62 | KDM4E (0.42) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604930-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2017-03-28 | — | — | US | disclosed |