Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830290 | 0.84 | CCNT1 (0.44) | PRMT5WDR77CDK9CCNT1 | |
| SCHEMBL15830035 | 0.80 | MAPK1 (0.50) | MAPK1PRMT5WDR77DYRK1ACLK2 | |
| SCHEMBL3504900 | 0.76 | MAPK1 (0.50) | MAPK1DYRK1ACLK2CLK3FYN | |
| SCHEMBL17826551 | 0.76 | MAPK1 (0.43) | MAPK1PRMT5WDR77DYRK1ACLK2 | |
| SCHEMBL18466256 | 0.76 | MAPK1 (0.43) | MAPK1PRMT5WDR77DYRK1ACLK2 | |
| SCHEMBL19633589 | 0.73 | MAPK1 (0.43) | MAPK1PRMT5WDR77CSNK1DMAPK14 | |
| SCHEMBL13436322 | 0.70 | MAPK1 (0.43) | MAPK1MAPK8MAPK9MAPK10CSNK1D | |
| SCHEMBL14349671 | 0.70 | MAPK1 (0.46) | MAPK1MAPK8MAPK9MAPK10FYN | |
| SCHEMBL20469081 | 0.69 | FYN (0.36) | FYN | |
| SCHEMBL13663477 | 0.69 | JAK3 (0.46) | MAPK1DYRK1ACLK2CLK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604930-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2017-03-28 | — | — | US | disclosed |